The response of tomato (Lycopersicon esculentum) to Nitrogen and potassium application in two wetland soils in Akwa Ibom State was studied. The studies included comparative pot trial and field experiment using tomato, general characterization of the soils at the locations (Odiok Itam and Ayadehe), determination of the nutrient content of both locations. The main objective of the study was to determin the growth rate of tomato in these soils and assessing the response of tomato to nitrogen and potassium fertilizer application. The physical parameters of the soils showed slight textural variation between Odiok Itam and Ayadehe locations. The soils in Odiok Itam were loamy sand while that of Ayadehe was sandy clay loam. The chemical parameters showed that these soils were generally acidic with a mean pH (HZO) value of 5.68 and a mean content of total N was 0.14%, while available K was 0.16 Cmol kg ‘l.