This study examined the influence of information technology on users’ patronage of polytechnic libraries in south south Nigeria. Three objectives, three research questions and three hypotheses were formulated to guide the study. The survey research design was used to conduct the study and the population of the study comprised 7,325 registered library users who are HND students in polytechnics in south south Nigeria. Accidental sampling technique was used to sample the sample size of 382 HND students from the study area. The instrument for data collection was the researcher made questionnaire titled “Information Technology on Users’ Patronage Questionnaire” (ITUPQ) and it was administered to the respondents with the aid of research assistants. The instrument was collected as respondents completed the exercise. 382 copies of the questionnaire were given out while 376 copies were duly filled and returned for the analysis. Data obtained was analyzed using mean and standard deviation to answer the research questions while t-test was used to analyze the hypothesis. The study revealed that, the variables examined significant influence on users’ patronage of polytechnic libraries in south south Nigeria. The study therefore concluded that there is significant influence of information technology on users’ patronage of polytechnic libraries in south south Nigeria. The following recommendations were made among others; Internet services should be increased in polytechnic libraries to improve users’ patronage and multimedia technology should be made available to enhance users’ patronage in polytechnic libraries.