First introduced to check coastal erosion, Nypa fruticans has proven to be much more useful. Given the variety of potentials it possess, we decided to analyse the leaves, husks and midveins of this plant for phytochemical bases and also test the antimicrobial property of various extracts against Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa. Phytochemical screening revealed the presence of alkaloids and polyphenols, and absence of tannins and anthraquinones. Aqueous and ethanolic extracts of the midveins, leaves and husks showed good antimicrobial against all the test organisms. Varying concentrations of the ethanolic extract of the leaves revealed that at concentration of 5% and above gave absolute inhibition of E. coli. There is need to reconsider the reutilization of Nypa Palm in Nigeria.