The study was carried out to examine the antibacterial, antifungal activity, and minimum inhibitory concentrations (MIC) of the petroleum ether, aqueous and ethanolic extracts of Tetrapleura tetraptera and Piper guineense in additional to their phytochemical screening and proximate composition analyses. All analyses were done using standard techniques. The bacteria isolates used were Esherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa while the fungi were Aspergillus, Mucor and Rhizopus species. The highest inhibition of 37.50 mm was seen using aqueous extract of P. guineense on E. coli. Consistently, the ethanolic and petroleum ether of P. guineense was not inhibitory to P. aeruginosa and S. aureus. The minimum inhibitory concentration (MIC) of the P. guineense leaves and T. tetraptera fruits were 80 mg/ml for both